Police officers are warning residents in rural South Carolina to close their doors and windows after at least 43 monkeys escaped from a bioresearch lab.

The rhesus macaques hatched on Wednesday evening from an Alpha Genesis facility in Yemassee – just off I-95 in the south of the state.

According to its website, the company “provides primate research and development support to the scientific community.”

As of Thursday morning, none of the escaped primates had been recaptured.

“We want to reassure the community that there is no health risk associated with these animals,” Yemassee police said.

Police and Alpha Genesis staff have “strategically” placed traps in the area and are using thermal imaging cameras to track the monkeys.

According to police, residents were warned to “secure doors and windows to prevent these animals from entering homes.”

Residents are being told not to approach the wild monkeys and instead to call 911 and report the sighting.

The Beaufort County Sheriff’s Office and state agriculture and wildlife agencies are working with local police “to effectively and humanely manage this incident,” Yemassee police said.

It is unclear how the primates managed to escape.

Alpha Genesis Inc. did not immediately respond to The Post’s request for comment.

Rhesus monkeys are native to India and China and are known for their high intelligence, according to National Geographic.

The monkeys have a long history of medical and scientific research on humans – and even flew into space before humans.

Yemassee is a small town of about 1,000 residents in Beaufort and Hampton counties in the Lowcountry of South Carolina, approximately 50 miles northwest of Savannah, Georgia.